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Version: 14.12e (Release date: 2014-12-29-08:00)
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pan FGFR Inhibitor ARQ 087 (Code C104267)

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Terms & Properties

Preferred Name: pan FGFR Inhibitor ARQ 087

Definition: An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor ARQ 087 binds to and potently inhibits the activity of FGFR subtypes 1, 2 and 3. This may result in the inhibition of FGFR-mediated signal transduction pathways, tumor cell proliferation, tumor angiogenesis and tumor cell death in FGFR-overexpressing tumor cells. FGFR, a receptor tyrosine kinase, is upregulated in many tumor cell types and plays a key role in tumor cellular proliferation, differentiation, angiogenesis and survival.

Display Name: pan FGFR Inhibitor ARQ 087

Label: pan FGFR Inhibitor ARQ 087

NCI Thesaurus Code: C104267 (Search for linked caDSR metadata)

NCI Metathesaurus CUI: CL445613  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ARQ 087
pan FGFR Inhibitor ARQ 087

External Source Codes: 
ChEBI ID CHEBI:63453 (see ChEBI info)
NCI META CUI CL445613 (see NCI Metathesaurus info)
PDQ Closed Trial Search ID 744652 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 744652 (check for NCI PDQ open clinical trial info)

Other Properties:
code C104267
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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